Devilish Effects of Taz in Nonalcoholic Steatohepatitis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28068221.
- Also identified by DOI 10.1016/j.cmet.2016.10.006.
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Abstract
Nonalcoholic steatohepatitis leads to cirrhosis and cancer in a rising number of patients with metabolic syndrome. In this issue of Cell Metabolism, Wang et al. (2016) identify the transcriptional co-activator Taz as a driver of inflammation and fibrosis through the induction of Indian hedgehog in hepatocytes, which stimulates fibrogenesis by hepatic stellate cells.
Medical subject headings
- Fatty Liver
- Non-alcoholic Fatty Liver Disease