Transportable hyperpolarized metabolites.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28072398.
- Also identified by DOI 10.1038/ncomms13975 and PMC identifier 5234073.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Nuclear spin hyperpolarization of <sup>13</sup>C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the short lifetime of the hyperpolarized magnetization (typically <1 min), the polarization process must be carried out close to the point of use. Here we introduce a concept that markedly extends hyperpolarization lifetimes and enables the transportation of hyperpolarized metabolites. The hyperpolarized sample can thus be removed from the polarizer and stored or transported for use at remote MRI or NMR sites. We show that hyperpolarization in alanine and glycine survives 16 h storage and transport, maintaining overall polarization enhancements of up to three orders of magnitude.
Medical subject headings
- Magnetic Resonance Imaging
- Magnetic Resonance Spectroscopy
- Metabolomics
- Specimen Handling