First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 28073857.
- Also identified by DOI 10.1093/infdis/jiw493 and PMC identifier 5583641.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.
Medical subject headings
- Alanine
- Antibodies, Monoclonal
- Antiviral Agents
- Hemorrhagic Fever, Ebola
- Immunologic Factors
- Ribonucleotides
- Therapies, Investigational