Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/γPGA Nanoparticles Administered Using a Microneedle Patch.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28075069.
- Also identified by DOI 10.1002/adhm.201600750.
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Abstract
Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
Medical subject headings
- Ebola Vaccines
- Lactic Acid
- Nanoparticles
- Polyglutamic Acid
- Polyglycolic Acid
- Polylysine
- Vaccines, DNA