The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding?
Level V
Where this comes from
- Record sourced from PubMed, PMID 28075537.
- Also identified by DOI 10.1111/add.13551 and PMC identifier 5571444.
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Abstract
Preferential treatment of high-risk opioid-dependent pregnant women with methadone limits evidence of the comparative safety of buprenorphine versus methadone on infant outcomes. Adjustment for maternal characteristics that affect both treatment choices and birth outcomes is necessary to provide valid estimates of the effect of prenatal opioid agonist therapy exposure.
Medical subject headings
- Buprenorphine
- Methadone