Hypoxia and H<sub>2</sub>O<sub>2</sub> Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28079384.
- Also identified by DOI 10.1021/acs.nanolett.6b03848.
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Abstract
A glucose-responsive closed-loop insulin delivery system mimicking pancreas activity without long-term side effect has the potential to improve diabetic patients' health and quality of life. Here, we developed a novel glucose-responsive insulin delivery device using a painless microneedle-array patch containing insulin-loaded vesicles. Formed by self-assembly of hypoxia and H<sub>2</sub>O<sub>2</sub> dual-sensitive diblock copolymer, the glucose-responsive polymersome-based vesicles (d-GRPs) can disassociate and subsequently release insulin triggered by H<sub>2</sub>O<sub>2</sub> and hypoxia generated during glucose oxidation catalyzed by glucose specific enzyme. Moreover, the d-GRPs were able to eliminate the excess H<sub>2</sub>O<sub>2</sub>, which may lead to free radical-induced damage to skin tissue during the long-term usage and reduce the activity of GOx. In vivo experiments indicated that this smart insulin patch could efficiently regulate the blood glucose in the chemically induced type 1 diabetic mice for 10 h.
Medical subject headings
- Drug Carriers
- Glucose
- Hydrogen Peroxide
- Hypoglycemic Agents
- Insulin