30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology.
review · Level V
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- Record sourced from PubMed, PMID 28086098.
- Also identified by DOI 10.1016/j.cell.2016.12.012 and PMC identifier 5268070.
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Abstract
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.
Medical subject headings
- Inflammation
- NF-kappa B