GABA Signaling Stimulates β Cell Regeneration in Diabetic Mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28086099.
- Also identified by DOI 10.1016/j.cell.2016.12.006.
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Abstract
GABA and the antimalarial drug artemether, which acts on GABAergic pathways, can drive pancreatic cells with an α-cell phenotype toward a β-cell-like phenotype. As reported in two papers (Ben-Othman et al. and Li et al.), these drugs can stimulate the production of sufficient numbers of new β-like cells to reverse severe diabetes in mice.
Medical subject headings
- Diabetes Mellitus, Experimental
- Insulin-Secreting Cells