The Interfaces of Genetic Conflict Are Hot Spots for Innovation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28086100.
- Also identified by DOI 10.1016/j.cell.2016.12.007 and PMC identifier 5480287.
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Abstract
RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for the Cas9 scalpel.
Medical subject headings
- Endonucleases
- RNA