And the fat lady sings about phosphate and calcium.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28087005.
- Also identified by DOI 10.1016/j.kint.2016.11.009.
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Abstract
Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity.
Medical subject headings
- Calcium
- Calcium, Dietary