Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin.
basic_science · Level V
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- Record sourced from PubMed, PMID 28095424.
- Also identified by DOI 10.1371/journal.pone.0169578 and PMC identifier 5240955.
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Abstract
The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.
Medical subject headings
- Inclusion Bodies
- Sesquiterpenes
- beta-Cyclodextrins