How does leptin restore euglycemia in insulin-deficient diabetes?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28112680.
- Also identified by DOI 10.1172/JCI91880 and PMC identifier 5272168.
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Abstract
Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.
Medical subject headings
- Diabetes Mellitus, Type 1
- Leptin
- Lipolysis