Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle-Like Functions.

Balasubramanian, Vimalkumar; Correia, Alexandra; Zhang, Hongbo; Fontana, Flavia; Mäkilä, Ermei; Salonen, Jarno; Hirvonen, Jouni; Santos, Hélder A · Adv Mater · 2017

basic_science · Level V

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Abstract

A new biomimetic nanoreactor design is presented based on cancer cell membrane material in combination with porous silicon nanoparticles. This cellular nanoreactor features a biocompartment enclosed by a cell membrane and readily integrated with cells and supplementing the cellular functions under oxidative stress. The study demonstrates the impact of the nanoreactors on improving cellular functions with a potential to serve as artificial organelles.

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