Chitosan-Gated Magnetic-Responsive Nanocarrier for Dual-Modal Optical Imaging, Switchable Drug Release, and Synergistic Therapy.

Wang, Hui; Mu, Qingxin; Revia, Richard; Wang, Kui; Zhou, Xuezhe; Pauzauskie, Peter J; Zhou, Shuiqin; Zhang, Miqin · Adv Healthc Mater · 2017

basic_science · Level V

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Abstract

A dual-layer shell hollow nanostructure as drug carrier that provides instant on/off function for drug release and contrast enhancement for multimodal imaging is reported. The on-demand drug release is triggered by irradiation of an external magnetic field. The nanocarrier also demonstrates a high drug loading capacity and synergistic magnetic-thermal and chemotherapy.

Medical subject headings