Detection of vulnerable neurons damaged by environmental insults in utero.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28123061.
- Also identified by DOI 10.1073/pnas.1620641114 and PMC identifier 5338500.
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Abstract
Development of prognostic biomarkers for the detection of prenatally damaged neurons before manifestations of postnatal disorders is an essential step for prevention and treatment of susceptible individuals. We have developed a versatile fluorescence reporter system in mice enabling detection of Heat Shock Factor 1 activation in response to prenatal cellular damage caused by exposure to various harmful chemical or physical agents. Using an intrautero electroporation-mediated reporter assay and transgenic reporter mice, we are able to identify neurons that survive prenatal exposure to harmful agents but remain vulnerable in postnatal life. This system may provide a powerful tool for exploring the pathogenesis and treatment of multiple disorders caused by exposure to environmental stress before symptoms become manifested, exacerbated, and/or irreversible.
Medical subject headings
- Cerebral Cortex
- Heat Shock Transcription Factors
- Neurons
- Prenatal Exposure Delayed Effects
- Response Elements