Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 28129361.
- Also identified by DOI 10.1371/journal.pone.0170545 and PMC identifier 5271335.
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Abstract
In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.
Medical subject headings
- Caffeine
- Hypoxia-Ischemia, Brain
- Neurons
- Neuroprotective Agents