A Receptor on Acid.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28129534.
- Also identified by DOI 10.1016/j.cell.2017.01.012 and PMC identifier 5520807.
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Abstract
Wacker et al. report the crystal structure of LSD in complex with one of its major targets in the brain, the 5-HT<sub>2B</sub> receptor, the first such structure for any psychedelic drug. The results shed light on the molecular mechanisms underlying its ability to induce hallucinations with greater duration and potency than closely related compounds.
Medical subject headings
- Hallucinogens
- Lysergic Acid Diethylamide