A Red Carpet for Iron Metabolism.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28129536.
- Also identified by DOI 10.1016/j.cell.2016.12.034 and PMC identifier 5706455.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
200 billion red blood cells (RBCs) are produced every day, requiring more than 2 × 10<sup>15</sup> iron atoms every second to maintain adequate erythropoiesis. These numbers translate into 20 mL of blood being produced each day, containing 6 g of hemoglobin and 20 mg of iron. These impressive numbers illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regulation of iron homeostasis and its disorders.
Medical subject headings
- Erythroid Cells
- Iron