Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28134339.
- Also identified by DOI 10.1038/ncomms14146 and PMC identifier 5290270.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue in non-cold-acclimated men given a standard liquid meal containing the long-chain fatty acid PET tracer, 14(R,S)-[<sup>18</sup>F]-fluoro-6-thia-heptadecanoic acid (<sup>18</sup>FTHA). However, the net contribution of BAT to systemic DFA clearance is comparatively small. Despite a 4-week cold acclimation increasing BAT oxidative metabolism 2.6-fold, BAT DFA uptake does not increase further. These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues.
Medical subject headings
- Acclimatization
- Adipose Tissue, Brown
- Dietary Fats
- Lipid Metabolism
- Thermogenesis