Engineered Multifunctional Nanomedicine for Simultaneous Stereotactic Chemotherapy and Inhibited Osteolysis in an Orthotopic Model of Bone Metastasis.
basic_science · Level V
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- Record sourced from PubMed, PMID 28134449.
- Also identified by DOI 10.1002/adma.201605754.
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Abstract
A novel multifunctional Ag<sub>2</sub> S quantum dot (QD)-based nanomedicine of alendronate (Ald)/doxorubicin (DOX)@Ag<sub>2</sub> S is developed for highly effective bone tumor therapy in an orthotopic model. The bone-targeting and osteolysis inhibition of Ald and the chemotherapeutic effect of DOX on the bone tumor are in situ visualized by Ag<sub>2</sub> S QDs with emission in the second near-infrared window.
Medical subject headings
- Antineoplastic Agents
- Bone Neoplasms
- Drug Delivery Systems
- Osteolysis
- Quantum Dots