Opioids: keeping the good, eliminating the bad.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28134927.
- Also identified by DOI 10.1038/nm.4277 and PMC identifier 6602584.
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Abstract
Two new studies show that mechanisms mediating the opioid side effects of tolerance, hyperalgesia and physical dependence are mediated spinally and can be dissociated from analgesia. These side effects can be selectively targeted by clinically available drugs without affecting their pain-relieving effects.
Medical subject headings
- Analgesics, Opioid
- Morphine