Building ProteomeTools based on a complete synthetic human proteome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28135259.
- Also identified by DOI 10.1038/nmeth.4153 and PMC identifier 5868332.
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Abstract
We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange.
Medical subject headings
- Chromatography, Liquid
- Proteome
- Proteomics
- Tandem Mass Spectrometry