Emergence of function from coordinated cells in a tissue.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28137861.
- Also identified by DOI 10.1073/pnas.1621145114 and PMC identifier 5321023.
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Abstract
This work presents a mathematical study of tissue dynamics. We combine within-cell genome dynamics and diffusion between cells, so that the synthesis of the two gives rise to the emergence of function, akin to establishing "tissue homeostasis." We introduce two concepts, monotonicity and a weak version of hardwiring. These together are sufficient for global convergence of the tissue dynamics.
Medical subject headings
- Cell Physiological Phenomena
- Models, Biological