Effects of NSAIDs and hydroxyapatite coating on osseointegration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28139193.
- Also identified by DOI 10.1177/2309499016684410.
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Abstract
The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration. Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and grit-blasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically. HA-coated implants had a significantly better failure load and "percentage of bone-implant contact" than grit-blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations. Our results indicate that NSAIDs did not have any negative effect on the osseointegration. HA-coated implants may provide more tensile strength and greater bone-implant contact rate in comparison with grit-blasted implants.
Medical subject headings
- Anti-Inflammatory Agents, Non-Steroidal
- Arthroplasty, Replacement, Hip
- Coated Materials, Biocompatible
- Durapatite
- Hip Prosthesis
- Osseointegration
Anatomy
- femur
- hip