Soil Primes the Seed: Epigenetic Landscape Drives Tumor Behavior.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 28157493.
- Also identified by DOI 10.1016/j.stem.2017.01.007 and PMC identifier 5800310.
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Abstract
Whether invasive tumor phenotypes like EMT arise from oncogenic drivers or from priming of the pre-tumor cell of origin remains unknown. In this issue of Cell Stem Cell, Latil et al. (2017) show that the pre-tumor niche establishes a chromatin state predisposing squamous cell carcinomas to undergo EMT and metastasis, suggesting that the pre-tumor epigenome has prognostic value.
Medical subject headings
- Carcinoma, Squamous Cell
- Soil