Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy.

Hu, Quanyin; Sun, Wujin; Qian, Chenggen; Bomba, Hunter N; Xin, Hongliang; Gu, Zhen · Adv Mater · 2017

basic_science · Level V

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Abstract

A "relay drug delivery" system based on two distinct modules, which is composed of a signal transmission nanocarrier A (NC<sub>A</sub> ) that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B (NC<sub>B</sub> ) that can accumulate at the tumor site by receiving the broadcasting signals generated by NC<sub>A</sub> , is developed for amplifying active tumor targeting signal and enhancing antitumor therapy.

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