Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28165174.
- Also identified by DOI 10.1002/adma.201605604.
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Abstract
An efficient system for direct delivery of integral membrane proteins is successfully developed using a new biocompatible exosome-based platform. Fusogenic exosomes harboring viral fusogen, vascular stomatitis virus (VSV)-G protein, can fuse with and modify plasma membranes in a process called "membrane editing." This can facilitate the transfer of biologically active membrane proteins into the target cell membranes both in vitro and in vivo.
Medical subject headings
- Biomimetic Materials
- Cell Membrane
- Exosomes
- Membrane Proteins
- Viral Proteins