Robust, universal biomarker assay to detect senescent cells in biological specimens.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28165661.
- Also identified by DOI 10.1111/acel.12545 and PMC identifier 5242262.
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Abstract
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan Black B (SBB) analogue suitable for sensitive and specific, antibody-enhanced detection of lipofuscin-containing senescent cells in any biological material. This new hybrid histo-/immunochemical method is easy to perform, reliable, and universally applicable to assess senescence in biomedicine, from cancer research to gerontology.
Medical subject headings
- Biological Assay
- Biomarkers
- Cellular Senescence