The Hunger Games: Salmonella, Anorexia, and NLRP3.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 28178561.
- Also identified by DOI 10.1016/j.cmet.2017.01.015.
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Abstract
Rao and colleagues (2017) reveal how Salmonella limits anorexia in mice, protecting them and promoting the spread of infection. The mechanism involves inhibition of the NLRP3 inflammasome limiting vagal nerve stimulation by IL-1β, which in turn promotes appetite. A possible new therapeutic approach for treating anorexia in multiple diseases is proposed.
Medical subject headings
- Anorexia
- Hunger