Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28181493.
- Also identified by DOI 10.1038/ncomms14253 and PMC identifier 5309800.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.
Medical subject headings
- Amines
- Dendritic Cells
- Receptors, CXCR4