Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.
Where this comes from
- Record sourced from PubMed, PMID 28182649.
- Also identified by DOI 10.1371/journal.pcbi.1005339 and PMC identifier 5300119.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.
Medical subject headings
- Genome, Human
- Genome, Viral
- HIV
- HIV Infections
- Models, Genetic
- Viral Load