Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28186488.
- Also identified by DOI 10.7554/eLife.22206 and PMC identifier 5367895.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1300 cell surface and ~7200 whole cell proteins, we demonstrate that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors. US18 and US20 work in concert to suppress cell surface expression of the critical NKp30 ligand B7-H6 thus inhibiting NK cell activation. The US12 family is therefore identified as a major new hub of immune regulation.
Medical subject headings
- Cytomegalovirus
- Host-Pathogen Interactions
- Immunologic Factors
- Killer Cells, Natural
- Membrane Proteins
- Viral Proteins