Transcriptional Addiction in Cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28187285.
- Also identified by DOI 10.1016/j.cell.2016.12.013 and PMC identifier 5308559.
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Abstract
Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.
Medical subject headings
- Neoplasms