Contribution of epigenetic mechanisms to variation in cancer risk among tissues.
basic_science · Level V
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- Record sourced from PubMed, PMID 28193856.
- Also identified by DOI 10.1073/pnas.1616556114 and PMC identifier 5338490.
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Abstract
Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads. We show that this variation is also correlated with the degree of aberrant CpG island DNA methylation in normal cells. Methylation accumulates during aging in a subset of molecules, suggesting that the epigenetic landscape within a founder-cell population may contribute to tumor formation.
Medical subject headings
- Aging
- Cell Transformation, Neoplastic
- Epigenesis, Genetic
- Models, Statistical
- Neoplasms
- Stem Cells