GHetting to know ADPKD proliferative signaling, STAT.
Level V
Where this comes from
- Record sourced from PubMed, PMID 28202165.
- Also identified by DOI 10.1016/j.kint.2016.11.024.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Due to their common pathogenesis and parallel proliferative signaling pathways, the cystic diseases have been recently studied in the context of cancer biology. The present study continues this paradigm by identifying signal transducer and activator of transcription (STAT5) and growth hormone (GH) as potentially modifiable pathways in polycystic kidney disease. GH, which is a potent activator of STAT5, has the additional possibility of being a biomarker, as well as providing a potential mechanism of action of somatostatin analogs in clinical trials.
Medical subject headings
- Polycystic Kidney, Autosomal Dominant
- STAT5 Transcription Factor