Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28202230.
- Also identified by DOI 10.1016/j.ebiom.2017.02.006 and PMC identifier 5360568.
- Licence recorded as CC BY-NC-ND.
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Abstract
Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future offspring, even if the offspring never experience febrile seizures. This transgenerational transmission was intensity-dependent and was mainly from mothers to their offspring. The transmission was associated with DNA methylation. Thus, our study supports a "Lamarckian"-like mechanism of pathogenesis and the crucial role of epigenetic factors in neurological conditions.
Medical subject headings
- Epigenesis, Genetic
- Seizures, Febrile