Transplantation of autologous chondrocytes <i>ex-vivo</i> expanded using Thermoreversible Gelation Polymer in a rabbit model of articular cartilage defect.
basic_science · Level V
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- Record sourced from PubMed, PMID 28203047.
- Also identified by DOI 10.1016/j.jor.2017.01.003 and PMC identifier 5293721.
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Abstract
Graft failure due to de-differentiation of the chondrocytes during in vitro culture and after transplantation is a major hurdle in Autologous Chondrocyte Implantation (ACI). We, herein, report the transplantation of autologous chondrocytes <i>ex vivo</i> expanded using a Thermo-reversible Gelation Polymer (TGP) in a rabbit model. A full thickness chondral defect was created in one of the knee joints in each of the six rabbits of the study and autologous chondrocytes <i>in vitro</i> expanded using TGP scaffold were transplanted after 10 weeks. H & E staining of the biopsy after 6 months revealed maintenance of articular cartilage phenotype.