Elevated Pre-Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 28203772.
- Also identified by DOI 10.1093/cid/cix155 and PMC identifier 5411394.
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Abstract
Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39+CD8+ T cell frequency was independently associated with mortality within 6 months of ART initiation.
Medical subject headings
- Antigens, CD
- Apyrase
- CD8-Positive T-Lymphocytes
- Coinfection
- HIV Infections
- Tuberculosis