Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 28203787.
- Also identified by DOI 10.1093/cid/cix140.
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Abstract
STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.
Medical subject headings
- Antibodies, Bacterial
- Immunoglobulin G
- Job Syndrome
- Staphylococcal Infections
- Staphylococcus aureus