Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28209790.
- Also identified by DOI 10.1161/CIRCRESAHA.117.310450 and PMC identifier 5319734.
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Abstract
We discuss the recent finding by Mizishima's group regarding the role of the autophagy-related conjugation system in mediating the closure of autophagosomes and its implication in the study of autophagy in mammalian cells. The study not only shows a novel function of the autophagy-related conjugation system but also indicates that mammalian cells are capable of generating autophagosomes even without it.
Medical subject headings
- Autophagosomes
- Autophagy
- Autophagy-Related Proteins