Investigations of silk fiber/calcium phosphate cement biocomposite for radial bone defect repair in rabbits.

Abstract

This study aimed to investigate the effects of silk fiber (SF)/calcium phosphate cement (CPC) biocomposite on repairing radial bone defects in rabbits. Four-month-old New Zealand rabbits were selected to create a bilateral radial bone defect model and divided into four groups according to implanted material: SF/CPC, SF/CPC/particulate bone (PB), PB, and control (C). The specimens were removed at four and eight postoperative weeks for general observation, X-ray examination, tissue slicing, scanning electron microscopy (SEM), and biomechanical testing. Postoperative X-ray showed no bone defect repair in group C and different degrees of bone defect repair in the other three groups. Imaging, histology, and SEM showed the following: group SF/CPC formed fine trabecular bone in week 4, while the maximum bending load in group SF/CPC in week 4 was significantly different from those in the other groups (P < 0.05). SF/CPC has good biocompatibility and bone-inducing ability, demonstrating its bone defect-repairing ability.