Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 28223688.
- Also identified by DOI 10.1038/ncomms14265 and PMC identifier 5322534.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Lumbar disc herniation (LDH) is common and often debilitating. Microdiscectomy of herniated lumbar discs (LDHsurg) is performed on the most severe cases to resolve the resulting sciatica. Here we perform a genome-wide association study on 4,748 LDHsurg cases and 282,590 population controls and discover 37 highly correlated markers associating with LDHsurg at 8q24.21 (between CCDC26 and GSDMC), represented by rs6651255[C] (OR=0.81; P=5.6 × 10<sup>-12</sup>) with a stronger effect among younger patients than older. As rs6651255[C] also associates with height, we performed a Mendelian randomization analysis using height polygenic risk scores as instruments to estimate the effect of height on LDHsurg risk, and found that the marker's association with LDHsurg is much greater than predicted by its effect on height. In light of presented findings, we speculate that the effect of rs6651255 on LDHsurg is driven by susceptibility to developing severe and persistent sciatica upon LDH.
Medical subject headings
- Chromosomes, Human, Pair 8
- Genetic Predisposition to Disease
- Genetic Variation
- Intervertebral Disc Degeneration
- Intervertebral Disc Displacement
- Lumbar Vertebrae
- Sciatica