The Salmonella effector SseJ disrupts microtubule dynamics when ectopically expressed in normal rat kidney cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 28235057.
- Also identified by DOI 10.1371/journal.pone.0172588 and PMC identifier 5325298.
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Abstract
Salmonella effector protein SseJ is secreted by Salmonella into the host cell cytoplasm where it can then modify host cell processes. Whilst host cell small GTPase RhoA has previously been shown to activate the acyl-transferase activity of SseJ we show here an un-described effect of SseJ protein production upon microtubule dynamism. SseJ prevents microtubule collapse and this is independent of SseJ's acyl-transferase activity. We speculate that the effects of SseJ on microtubules would be mediated via its known interactions with the small GTPases of the Rho family.
Medical subject headings
- Acyltransferases
- Bacterial Proteins
- Epithelial Cells
- Host-Pathogen Interactions
- Microtubules
- Salmonella typhimurium
- rho GTP-Binding Proteins