Mutational Processes Shaping the Genome in Early Human Embryos.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28235191.
- Also identified by DOI 10.1016/j.cell.2017.02.008.
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Abstract
In-vitro-fertilized human embryos often acquire large structural and numerical chromosomal abnormalities. Liu et al. now show that multiple smaller copy number variations may also arise in in-vivo-conceived embryos. Analysis of these variations provides insight into the DNA mutational processes occurring in early embryos and the mechanisms underlying them.
Medical subject headings
- DNA Copy Number Variations
- Fertilization in Vitro