Gut-Brain Cross-Talk in Metabolic Control.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 28235194.
- Also identified by DOI 10.1016/j.cell.2017.01.025 and PMC identifier 5839146.
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Abstract
Because human energy metabolism evolved to favor adiposity over leanness, the availability of palatable, easily attainable, and calorically dense foods has led to unprecedented levels of obesity and its associated metabolic co-morbidities that appear resistant to traditional lifestyle interventions. However, recent progress identifying the molecular signaling pathways through which the brain and the gastrointestinal system communicate to govern energy homeostasis, combined with emerging insights on the molecular mechanisms underlying successful bariatric surgery, gives reason to be optimistic that novel precision medicines that mimic, enhance, and/or modulate gut-brain signaling can have unprecedented potential for stopping the obesity and type 2 diabetes pandemics.
Medical subject headings
- Brain
- Energy Metabolism
- Gastrointestinal Tract