Orthogonal near-infrared upconversion co-regulated site-specific O<sub>2</sub> delivery and photodynamic therapy for hypoxia tumor by using red blood cell microcarriers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28235648.
- Also identified by DOI 10.1016/j.biomaterials.2017.02.017.
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Abstract
Pre-existing hypoxia in tumors can result in an inadequate oxygen supply during photodynamic therapy (PDT), which in turn hampers photodynamic efficacy. To overcome this problem, we developed an orthogonal near-infrared upconversion controlled red blood cell (RBC) microcarriers to selectively deliver O<sub>2</sub> in hypoxia area. Moreover, this RBC microcarriers are able to overcome a series of complex biological barriers which include transporting across the inflamed endothelium, evading mononuclear phagocyte system, reducing reticuloendothelial system uptake. Based on these abilities, RBC microcarriers have efficient tumors accumulation and are capable of delivery a large amount of O<sub>2</sub> for PDT under near-infrared (NIR) irradiation to realize effective solid tumor eradication.
Medical subject headings
- Delayed-Action Preparations
- Erythrocyte Transfusion
- Erythrocytes
- Neoplasms, Experimental
- Oxygen
- Photochemotherapy
- Tumor Hypoxia