Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28241014.
- Also identified by DOI 10.1371/journal.pone.0171674 and PMC identifier 5328247.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The oral administration of rebamipide decreased plaque formation in atherosclerotic lesions as well as the markers of metabolic disorder in ApoE-deficient mice with atherosclerosis. Pro-inflammatory cytokines were also suppressed by rebamapide. In addition, the population of Th17 was decreased, whereas Treg was increased in the spleen of rebamipide-treated ApoE deficient mice. Rebamipide also ameliorated the severity of obese arthritis and has the capability to reduce the development of atherosclerosis by controlling the balance between Th17 and Treg cells. Thus, rebamipide could be a therapeutic agent to improve the progression of inflammation in metabolic diseases.
Medical subject headings
- Alanine
- Atherosclerosis
- Inflammation
- Lipid Metabolism
- Quinolones