Shifting the Focus of Preclinical, Murine Atherosclerosis Studies From Prevention to Late-Stage Intervention.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 28254801.
- Also identified by DOI 10.1161/CIRCRESAHA.116.310101 and PMC identifier 5338643.
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Abstract
Could improving the design of preclinical murine atherosclerosis studies help increase the success rate of cardiovascular clinical trials? In this <i>Viewpoint</i>, the authors advocate for a change from prevention to intervention study designs and rigorous lesion analyses which they argue will enhance the translational potential of murine atherosclerosis studies.
Medical subject headings
- Atherosclerosis