<i>ZNF50</i>3/<i>Zpo2</i> drives aggressive breast cancer progression by down-regulation of GATA3 expression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28258171.
- Also identified by DOI 10.1073/pnas.1701690114 and PMC identifier 5373372.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The transcription factor GATA3 is the master regulator that drives mammary luminal epithelial cell differentiation and maintains mammary gland homeostasis. Loss of <i>GATA3</i> is associated with aggressive breast cancer development. We have identified ZNF503/ZEPPO2 zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional repressor of <i>GATA3</i> expression and transcriptional activity that induces mammary epithelial cell proliferation and breast cancer development. We show that ZPO2 is recruited to <i>GATA3</i> promoter in association with ZBTB32 (Repressor of GATA, ROG) and that ZBTB32 is essential for down-regulation of <i>GATA3</i> via ZPO2. Through this modulation of GATA3 activity, ZPO2 promotes aggressive breast cancer development. Our data provide insight into a mechanism of GATA3 regulation, and identify ZPO2 as a possible candidate gene for future diagnostic and therapeutic strategies.
Medical subject headings
- Breast Neoplasms
- GATA3 Transcription Factor
- Gene Expression Regulation, Neoplastic