Diagnosis of Zika virus infection on a nanotechnology platform.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 28263312.
- Also identified by DOI 10.1038/nm.4302.
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Abstract
We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.
Medical subject headings
- Antibodies, Viral
- Immunoglobulin A
- Immunoglobulin G
- Nanotechnology
- Viral Nonstructural Proteins
- Zika Virus Infection